Marcus Rashford notably scored twice in Barcelona’s commanding 6-1 victory over Olympiacos.
A remarkable 43 goals were tallied, accompanied by five red cards and six penalties awarded, with five successfully converted.
Tuesday delivered a relentless evening of Champions League action.
Reigning champions Paris St-Germain overwhelmed Leverkusen with a 7-0 victory, despite both teams suffering a dismissal and Leverkusen’s Alejandro Grimaldo failing to convert a penalty.
PSV Eindhoven mounted a spirited comeback from an early deficit, ultimately securing a dominant 6-2 win against Italian champions Napoli.
Arsenal, Newcastle, and Manchester City all claimed convincing victories, with Erling Haaland of City extending his scoring streak to a 12th consecutive game.
With an abundance of goals and dramatic moments, BBC Sport delves into the key statistics behind an unforgettable night in Europe’s premier club competition.
Only twice before has a Champions League night witnessed a higher goal tally than Tuesday’s goalfest.
Last season’s final group stage round saw a record 64 goals scored across all matches.
However, with all 18 games played simultaneously, the goals-per-game average was slightly lower at 3.55.
On 1 October 1997, 44 goals were scored across 12 games, with notable contributions from Paul Scholes and Zinedine Zidane as Manchester United defeated Juventus 3-2 at Old Trafford.
Analyzing the statistics from a goals-per-game perspective across multiple matches, Tuesday night is second only to one other Champions League evening.
That occurred 11 years ago on 21 October 2014, when 40 goals were scored in eight games, averaging five goals per game.
Sergio Aguero and James Milner were among the scorers for Manchester City in a 2-2 draw against CSKA Moscow, well before the club’s eventual Champions League triumph.
Chelsea dominated Maribor with a 6-0 victory on the same night, while Bayern Munich and Shakhtar Donetsk each scored seven goals in their respective wins against Roma and Bate Borisov.
English clubs collectively scored the most goals on Tuesday with nine, closely followed by France, spearheaded by Paris St-Germain, with seven.
Only Union Saint-Gilloise (Belgium), Benfica (Portugal), Kairat (Kazakhstan), and Pafos (Cyprus) failed to find the net.
English players contributed five goals, with Marcus Rashford of Barcelona and Harvey Barnes of Newcastle each scoring twice, and Anthony Gordon also finding the net for the Magpies.
However, Spanish players scored the most, with Barcelona’s Fermin Lopez netting a hat-trick, accounting for half of the six goals scored by players from his nation.
Football Daily – UCL Debrief: Faultless night for Premier League sides in Europe
Latest Champions League table
Champions League scores & fixtures
Follow the latest Champions League news
Get football news sent straight to your phone
Watch highlights of every Champions League game from 22:00 on Wednesday on BBC iPlayer and the BBC Sport website and app.
There will also be a Champions League Match of the Day on BBC One on Wednesday, from 22:40 to 00:00.